What does the literature support?
PRP has become a hot topic in the medical field. It has been advertised for use in many different supposed medical applications. Is PRP effective or just another marketing gimmick? The following are just a few examples within the current literature supporting a growing body of data for PRP use in orthopedic applications.
The American Academy of Orthopedic Surgeons recently published an overview summary article on PRP for knee osteoarthritis. It stated that current literature and scientific data supported PRP for knee arthritis treatment over steroid injections, hyaluronic acid, NSAIDs, exercise, ozone, prolotherapy, and bone marrow aspirate concentrate. JAAOS
A meta analysis from the American Journal of Sports Medicine showed that rotator cuff repairs when enhanced with PRP have fewer retears occurrence than in patients who received a standard non-PRP rotator cuff repair. AJSM, ASMR, JCM
A recent double blinded controlled trial compared PRP with steroid injections for rotator cuff tendinopathy that hadn’t improved with other treatments. PRP outperformed steroid injections for functional and pain improvement out to the 12 month follow up. JSES
PRP for lateral epicondylitis of the elbow. OJSM
Does the dose matter?
The amount of platelets and growth factors within each person is affected by many factors. When making a recipe, the amount of each ingredient is important. Leaving out even just a portion of an ingredient will change the taste and appearance of the meal. The same can be said for PRP. Based on published studies, an effective dose concentration of PRP is over 3.5 billion platelets with high dose being over 5 billion. OJSM and Biomedicines